NIH R01 · 2025
Inflammatory Signaling in the Leptomeninges
PROJECT SUMMARY Leptomeningeal metastasis (LM) or spread of tumors into the spinal fluid-filled spaces that surround the brain and spinal cord represents an increasingly common, lethal complication of malignancy. A hallmark of LM is the robust inflammation that accompanies cancer cell growth in this space. Despite this inflammatory response to tumor, cancer cells invariably grow and overtake this space. We hypothesize that cancer within the leptomeningeal space derives benefit from this inflammatory signaling. Leveraging a collection of clinical samples obtained during the course of radiation treatment, we find that levels of CXCL1 increase in the spinal fluid in the setting of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.