NIH R01 · 2025
Glutamatergic neurotransmission in gut neuropod cells
SUMMARY Despite the clear link between sugar overconsumption and metabolic syndrome, how the gut senses and communicates the presence of sugar to the brain remains unknown. Studies have shown that preference for sugars depends not on their sweet taste in the oral cavity, but rather on their entrance into the intestine. Therefore, understanding how the gut communicates information about ingested sugars could open a new path for pharmacotherapeutics for treating metabolic disease. The mechanisms of sensing nutrients in the gut are thought to involve the slower paracrine and endocrine action of peptides released from enteroendocrine cells. In recent years it has become evident that in addition…
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