NIH R01 · 2025
Pexophagy regulation in live animals and its role in aging and longevity
Project Summary/Abstract Aging often manifests as physiological decline at an organismal level. However, the aging process has its roots at the level of cells; changes to molecules and cellular compartments ultimately underlie physiological decline and age-related disease pathology. Clarifying cellular causes of aging has the potential to inform strategies to promote longer, healthier lives, and may also reveal unexpected elements of cell biology relevant to animal health and disease. My lab has begun analysis of a new aspect of cell biology in aging: degradation of peroxisomes by autophagy. Peroxisomes are membrane-bound eukaryotic organelles that are critical to cell health and organismal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.