NIH R01 · 2025
Novel Probes of the Kappa Opioid Receptor: Chemistry, Pharmacology, and Biology
Project Summary We propose to develop new kappa opioid receptor (KOR) agonists that have diverse signaling profiles with the goal of correlating cellular signaling properties to favorable properties (antipruritic, anxiolytic and non-sedating) in mice. The KOR is an attractive drug target because drugs that activate KOR do not lead to overdose or addiction. However, drugs that act at KOR have had their own side effects that have hampered their use clinically. These include diuresis, dysphoria and sedation. Our prior work has introduced new probe compounds that raise the possibility that the therapeutic effects may be separated from the side effects. Compound triazole 1.1 is a potent KOR…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.