NIH R01 · 2025
Assay for Detection of Homologous DNA Interactions
Project Summary Homologous DNA interactions are a key determinant of chromosome structure and genome function. In mitotic cells, pairing between sister chromatids ensures faithful chromosome segregation and efficient chromosome break repair. In the germ line, pairing between homologous chromosomes is a precondition for genetic exchange during meiosis, ensuring segregation of homologous chromosomes and creation of novel allele combinations. Defects in homologous DNA pairing contribute to chromosome missegregation and gross chromosome rearrangements, conditions associated with cancer, premature aging and birth defects. Moreover, allele choice for monoallelic gene expression is also thought to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.