NIH R01 · 2025
PROJECT SUMMARY Background: Aspirin is recommended in high risk pregnancies to reduce the risk of preeclampsia and preterm birth, but up to 20% will still have these adverse outcomes. Recommendations for aspirin dose range from 75mg-162mg daily. Gaps in knowledge regarding pregnancy specific aspirin pharmacology and relationship between aspirin response and pregnancy outcome limit optimal use of aspirin to prevent adverse perinatal outcomes. Objective: 1) Determine platelet inhibition in response to increased dosing of aspirin through gestation and factors impacting aspirin response. 2) Determine aspirin population pharmacokinetics (PK) and PK/PD (pharmacodynamic) relationship through…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.