NIH R01 · 2024
Neurogenesis in the adult Drosophila brain
Project Summary One of the barriers to therapeutic neural regeneration in humans is the absence of neural stem cells in most regions of the adult brain. Nonetheless, it would be advantageous to induce regeneration from resident cells. In addition, progress in the field would be accelerated if neural regeneration from resident cells could be investigated using a genetic model organism. Toward this end, we have developed a novel adult neurogenesis model in the Drosophila melanogaster central brain. We find that despite the absence of known neural progenitors, cells in the adult Drosophila central brain proliferate following injury, giving rise to both new neurons and new glial cells. Further,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.