NIH R01 · 2024
Genetic Control of Cardiac Development: Congenital Heart Disease Gene Discovery in Drosophila
PROJECT SUMMARY Congenital heart defects/diseases (CHDs) are the most common developmental anomalies and are the leading non-infectious causes of mortality in newborns, underscoring the importance of studying the underlying causes. The main genetic contributors are known for only 10-15% of CHD patients, thus hundreds more have yet to be discovered. It is our goal to systematically elucidate the genetic basis of CHDs. This is particularly challenging in mammalian models due to their genetic complexity and the often oligogenic nature of CHDs. We and others have originally defined a first set of ‘cardiogenic’ genes in Drosophila that specify the heart (e.g. tinman/Nkx2-5). These insights…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.
← All labs at Sanford Burnham Prebys Medical Discovery Institute