NIH R01 · 2025
PROJECT ABSTRACT Small cell lung cancer (SCLC) and neuroendocrine prostate cancer (NEPC) are aggressive, high-grade neuroendocrine neoplasms (HG-NENs) that often metastasize and do not respond well to treatment. Lung cancer is the leading cause of cancer mortality worldwide and SCLC represents ~15% of lung cancers. Prostate cancer is the most common solid tumor and the second-leading cause of cancer-related death among men in the US. More than 20% of males with advanced prostate cancer eventually develop the highly aggressive NEPC form. Both SCLC and NEPC are characterized by similar genetic (RB1 and TP53 loss) and phenotypic features, as well as substantial intra-tumoral heterogeneity,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.