Bobay Lab

North Carolina State University Raleigh

BIOLOGY

Raleigh · United States

NIH-funded
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NIH R01 · 2024

Investigating the Impact and Patterns of Homologous Recombination and Adaptive Evolution on Bacterial Genomes

Project summary In contract to sexual organisms, the mechanisms of population genetics in bacteria are far less understood. Two fundamental aspects of bacterial population genetics remain sorely understudied: i) the impact of DNA exchange on the evolution of bacterial genomes and populations is largely unknown. ii) the prominence of adaptive evolution has not been comprehensively assessed in bacteria. Determining how recombination and adaptive evolution impact bacteria is key to understand the biology of these organisms and to develop relevant models of their evolution. Although bacteria reproduce clonally, there is increasing evidence that the vast majority of these organisms are capable…

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