NIH R01 · 2024
PHARMACOLOGICAL TARGETING OF GALPHA SUBUNITS IN DISEASE
Project Summary/Abstract This multi-PI basic science project aims to transform understanding of G-protein function in physiology and disease, and provide broadly applicable routes for developing therapeutics to treat currently untreatable diseases caused by mutant constitutively active G protein α-subunits. It does so by developing knowledge required to design and synthesize, at scales required for preclinical and eventual clinical studies, a family of bioavailable inhibitors, each of which selectively targets closely related groups of heterotrimeric G proteins. The translational/clinical potential of this approach is based on recent studies indicating that a bioavailable inhibitor that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.