Blue Lab

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NIH R01 · 2025

Integrating multi-omics data to understand the heterogeneity of preeclampsia and long-termpostpartum hypertension

PROJECT SUMMARY Preeclampsia (PE) is a pregnancy-specific syndrome of progressive vascular dysfunction that leads to escalating hypertension and extensive maternal organ damage, which can ultimately result in death. Occurring in 5-8% of pregnancies worldwide, PE is a leading cause of both maternal and perinatal mortality. Beyond the short-term risks, PE survivors suffer a 2-6-fold increase in lifelong risk of future hypertension (HTN), heart failure, stroke, and cardiovascular (CV)-specific mortality. Despite its high incidence, the underlying genetic and environmental contributions to PE is lacking. Recent advances now allow for the simultaneous analysis of multiple types of omics data…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.