NIH R01 · 2025
Cardiac function and proteomic biomarkers in individuals with perinatal HIV infection or exposure
There are approximately three million individuals with perinatally acquired human immunodeficiency virus (pnHIV) worldwide and >150,000 new youth with pnHIV (YpnHIV) annually. The incidence of pnHIV has declined dramatically over the last two decades, yet rates remain high in Eastern and Southern sub-Saharan Africa (SSA) - threefold greater than the global average. Prior studies from SSA have been unable to resolve whether pnHIV increases risk of cardiac or physical dysfunction compared to unexposed children or those with perinatal HIV exposure but who are HIV seronegative (PHEU). Elucidating determinants of cardiac, autonomic and physical dysfunction in the disproportionately affected…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.