NIH R01 · 2024
Structure and Function of a Eukaryotic Centromere
Project Summary Goals: The centromere serves as the binding site for the kinetochore and is essential for the faithful segregation of chromosomes throughout cell division. The point centromere in yeast is encoded by a ~115 bp specific DNA sequence, whereas regional centromeres span 6-10 kbp in fission yeast to 5-10 Mbp in human. Despite the apparent diversity in centromere organization, the distance between sister kinetochores in metaphase ranges from 800 nm to 1,000 nm in yeast, worms, flies, flower moths, plants, horses and human. Understanding the physical structure of centromere chromatin (pericentromere in yeast, defined as the chromatin between sister kinetochores) will provide…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.