NIH R01 · 2024
Complete mapping of immune selection from antibodies to HIV
PROJECT SUMMARY This isolation of exceptionally broad anti-HIV antibodies has revealed sites of vulnerability on the virus’s surface protein, Env. Major efforts are now underway to elicit such antibodies with vaccines, or to use the antibodies directly as therapeutics. The design of such vaccines and therapies requires carefully characterizing how monoclonal antibodies and polyclonal sera recognize Env. We have recently developed a new deep-sequencing based approach to functionally characterize antibody-Env interactions on a large scale. Here we will greatly extend the utility of this approach by making it possible to easily and completely map the effects of all amino-acid mutations on…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.