NIH R01 · 2024
PROJECT SUMMARY/ABSTRACT Maximal surgical resection of the most common primary brain cancer, glioblastoma (GBM), has been shown to improve overall survival in a highly morbid disease. However, delineation of residual tumor at the margins of surgical resections can be challenging using conventional techniques, and therefore the use of fluorescence guided surgery (FGS) has emerged as an adjuvant tool for tumor detection. At present, only one agent, 5- aminoleveulinic acid (5-ALA), is approved for detection of GBM during surgery. Metabolism of 5-ALA into protoporphyrin IX (PpIX) is detected qualitatively by wide-field fluorescence imaging through the surgical microscope. This intensity-based…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.