NIH R01 · 2024
Transcriptional Networks Controlling Erythroid Differentiation
Abstract The spatial organization of chromosomes and gene expression are mutually influential processes. Perturbations of either can lead to developmental defects and disease. Studies on chromatin structure have been dominated by those focusing on the architectural transcription factors CTCF, YY1 and the cohesin complex. The central hypothesis of this application, supported by preliminary data, is that the non-DNA binding adapter protein Ldb1 presents a separate, equally important category of nuclear chromatin organizers. In prior work we demonstrated that artificial recruitment of Ldb1 to chromatin can be sufficient to forge long range enhancer- promoter contacts at the b-globin locus.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.