NIH R01 · 2025
Regulation of host innate and adaptive immunity by bacterial type III effectors
Project Summary/Abstract Bacterial pathogens use type III secretion systems to translocate effectors into host cells to promote virulence. Type III secretion can also activate compensatory innate immune responses that are host protective. For example, type III secretion can trigger inflammasome assembly in host cells, resulting in release of the cytokine IL-1b. Virulent pathogens can inhibit compensatory protective immune responses triggered by type III secretion but how this is achieved at the cellular and molecular levels in vivo remains poorly understood. To address this knowledge gap, this project seeks to determine at the cellular and molecular levels how type III secretion effectors…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.