NIH R01 · 2024
PROJECT SUMMARY Opioid addiction is a chronic, progressive disorder that fuels the current US epidemic of opioid overdose deaths. Over the years, a tremendous amount of research effort has been devoted to understanding the biological roles of opioid receptors and developing newer generations of synthetic opioids to treat pain and combat opioid addiction. However, given the advancement of contemporary and novel neuroscience technologies, we have the tools to think beyond mu-opioid receptors (MORs) to develop improved OUD therapeutics. This proposal aims to investigate the architecture and function of endogenous MOR-expressing neural circuits in the brain and to determine how these circuits…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.