Blemker Lab

University of Virginia

BIOMEDICAL ENGINEERING

Charlottesville · United States

NIH-funded
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NIH R01 · 2025

A quantitative framework to examine sex differences in musculoskeletal scaling and function

SUMMARY The goal of this proposal is to develop a quantitative framework to address sex as a biological variable in musculoskeletal modeling and simulation research. This new framework will allow the field to understand how sex differences in musculoskeletal structure influence movement biomechanics, musculoskeletal injury, and neuromuscular disease. There are many known differences in bone anatomy, joint mechanics, muscle architecture, and movement function between males and females. Likewise, it is well documented that there are significant sex differences in susceptibility to musculoskeletal injury and neuromuscular disease. However, while the use of computer simulations of movement to…

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