NIH R01 · 2024
Control of Muscle Stem Cells to Enhance Regeneration
PROJECT SUMMARY According to the most recent U.S. Census, the elderly population will more than double to 80 million, encompassing 1 in 5 Americans by 2050. Aging is characterized by a decline in tissue function and regenerative capacity. Sarcopenia, also known as age-dependent loss of skeletal muscle mass and strength, is a major public- health problem that affects 15% of the elderly, leading to loss of mobility and diminished quality of life. Age- related muscle loss is paralleled by a loss in the function of muscle stem cells (MuSCs), key players in muscle homeostasis and regeneration. However, the mechanisms responsible for age-associated MuSC dysfunction remain elusive. Two major…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.