NIH R01 · 2024
ABSTRACT The goal of this project has been and remains to gain understanding of the biochemical basis for our observation that retinol-binding protein 2 (RBP2) has an unsuspected role in the maintenance of body weight, normal responses to a glucose challenge, and normal fasting hepatic triglyceride levels. We found that when maintained solely on a control chow diet, 6-7-month-old Rbp2-deficient (Rbp2-/-) mice accrue significantly more body weight as white adipose tissue (WAT), respond significantly less well to a glucose challenge, and possess significantly more hepatic fat than matched wild type (WT) littermate controls. These phenotypes were fully recapitulated by younger 55-day old…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.