Blandino-Rosano Lab

Research focus

NIH R01 · 2025

Dynorphin, a novel paracrine factor that regulates insulin secretion

Dynorphin, a novel paracrine factor that regulates insulin secretion The inability to maintain glucose homeostasis leads to diabetes, a life-threatening disease of epidemic proportions. The adaptation of pancreatic islets to insulin resistance is a significant determinant of developing type 2 diabetes (T2D). Within the pancreatic islet, the crosstalk between different islet cells through paracrine signals orchestrates a hormonal response that controls glucose levels. Dysregulation of these signals contributes to impaired glucose homeostasis and diabetes. The long-term goal of my research program is to understand how paracrine interactions within islet cells regulate hormone secretion and…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.