NIH R01 · 2024
Hypothalamic Neuronal Activity During Insomnia Induced by Chronic Ethanol Exposure
Severe insomnia occurs during the withdrawal from chronic use of alcohol. To gain relief from insomnia, alcoholics begin drinking again. Although the cause of the insomnia is unknown, indirect measurements of neuronal activity (c-FOS, fMRI) suggest that during insomnia, more of the arousal- promoting neurons are hyperactive. The status of the sleep-promoting neurons is unknown but are likely to be less active. Our overall hypothesis is that it is the imbalance in activity between wake versus sleep-promoting neurons that is the basis of insomnia during the withdrawal from alcohol. We will directly test this hypothesis in a proven mouse model of chronic ethanol intoxication using newly…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.