NIH R01 · 2025
Chronic Stress, Glucocorticoids, and Progesterone in Brain Aging
Evidence indicates that prolonged/ repeated behavioral stress promotes brain aging. This is thought to be due, at least in part, to stress associated glucocorticoid (GC) secretion, which in turn binds to glucocorticoid receptors, exerting transcriptional and other effects. A key downstream mediator in this signaling pathway, serum-and- glucocorticoid kinase 1 (Sgk1) accelerates, and the female sex steroid progesterone (P4) blunts, the effects of GCs. However, despite the negative clinical consequences of chronic stress exposure with aging and/or in female subjects, little work has examined how aging may change the stress response, the mechanisms through which stress may accelerate brain…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.