Blackwood Lab

Research focus

NIH R01 · 2025

Roles for SGK1 in Cardiometabolic Heart Failure with Preserved Ejection Fraction

Project Summary: Heart failure with preserved ejection fraction (HFpEF) has emerged as the greatest unmet medical need in cardiovascular medicine, comprising 50% of all HF cases, with a US prevalence of ³3 million. HFpEF is associated with high morbidity and mortality, with a 5-year survival after hospitalization worse than most cancers of ~35% and, unlike the better understood heart failure with reduced ejected fraction (HFrEF), there are no evidence-based therapies for HFpEF. HFpEF represents an entirely new disease threat because of the systemic metabolic and endocrine nature of its pathogenesis. And, while HFpEF is heterogeneous in its clinical presentation, arguably the most prevalent…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.