NIH R01 · 2024
Structure and Function of Tetraspanin Complexes
Project Summary Tetraspanins are an ancient and exceptionally well-conserved family of four pass transmembrane proteins – numbering 33 unique members in humans – that have essential but poorly understood functions in many different cellular contexts. Among tetraspanin proteins, CD81 and the C8 subfamily stand out as particularly important in human biology. CD81 is a binding partner of CD19 in the B cell co-receptor complex, a key regulator of B cell receptor (BCR) signaling. Relatively little is known, however, about how the dynamic association of CD81 with CD19 regulates its association with the B cell receptor and ability to induce a signaling response, critical knowledge gaps that impede…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.