NIH R01 · 2025
Metabolic reprogramming of smooth muscle cells in pulmonary hypertension
Pulmonary hypertension (PH) is a devastating disease of the blood vessels in the lung in which excessive proliferation and impaired apoptosis contribute to vascular obstruction, right ventricular hypertrophy (RVH), RV failure and eventually death. We discovered that the hyperproliferative phenotype in the pulmonary artery smooth muscle layer is associated with a metabolic reprogramming that induces a Warburg phenotype. Further, we demonstrated that the loss of mitochondrial bioenergetics in pulmonary arterial smooth muscle cells (PASMC) isolated from pulmonary hypertensive rats (PH-PASMC) was due to a loss of electron transport chain (ETC) Complex I assembly and activity. However, the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.