NIH R01 · 2025
Mito-inflammation and sepsis-induced acute lung injury
SUMMARY Our prior work has shown that TLR4-mediated increases in mitochondrial (mt)-ROS play an essential role in the inflammatory phase of acute lung injury (ALI) by stimulating NF-kB and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activity. However, the molecular mechanisms by which mt-ROS stimulates inflammatory response are unresolved and are the focus of our application. The mitochondrial network constantly forms elongated tubes through fusion and splits into small, less-connected mitochondria through fission. Recent work has highlighted the importance of pathological mitochondrial network remodeling in human disease. Thus, optimizing mitochondrial network…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.