NIH R01 · 2024
Informatics strategies to improve immune-related adverse event detection in cancer patients
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have drastically improved cancer survival over the past decade, but this survival comes at the cost of a new class of immune-related adverse events (irAEs) characterized by inflammatory and auto-immune pathologies that occur and persist long after ICI discontinuation. These irAEs can have major impacts on long-term quality-of-life, but our ability to appropriately address them is limited by an insufficient understanding of irAE rates and severity profiles. Automated methods to identify and monitor irAEs could improve clinical care, biomedical research, and pharmacovigilance, however, irAEs are often only documented in clinical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.