Bispo Lab

Massachusetts Eye and Ear Infirmary

Boston · United States

NIH-funded
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NIH R01 · 2025

Point-of-Care Metagenomics for Rapid Detection of pathogens and Antimicrobial Resistance in Sight-Threatening Ocular Infections

PROJECT SUMMARY Timely and accurate diagnosis of ocular infections is critical to guide early effective therapy and save vision. However, because current methods for diagnosis of ocular infections are time-consuming and not sensitive, empirical treatment with broad-spectrum therapies selected on the basis of clinical judgment continues to be the mainstream approach. Since ocular infections are caused by a wide range of organisms, which may present with overlapping features, many patients are treated unnecessarily with inappropriate antimicrobials. These broad- spectrum scattershot approaches lead to increased toxicity, select for resistant bacteria, and are increasingly compromised by the…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.

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