Bishehsari Lab

University of Texas Hlth Sci Ctr Houston

INTERNAL MEDICINE/MEDICINE

Houston · United States

NIH-funded
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NIH R01 · 2025

Development of a precision medicine platform for circadian based therapeutics in pancreatic cancer

Abstract Pancreatic ductal adenocarcinoma (PDA) is among the most fatal of all cancers, and is on track to become the second-leading cause of cancer-related death in the US by 2030. There is significant heterogeneity among PDA tumors, mitigating the effectiveness of conventional chemotherapy and highlighting the need for more individualized approaches to treatment. Personalized medicine (PM) strategies, which take tumor and/or patient- specific data into account when deciding on a course of treatment, have shown great promise within the context of many different types of cancers in recent preclinical and clinical studies. However, most PM approaches rely on molecular profiling data that…

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