NIH R01 · 2024
Measuring Intralesional Drug Exposures in Cavitary TB using Noninvasive In Vivo PET Imaging
Effective treatment of infections depends on achieving adequate antibiotic concentrations at infection sites, where the pathogen resides. However, with few exceptions, current antibiotic dosing recommendations are based on achievable plasma concentrations, without specific information on drug concentrations at the site of infection. However, plasma drug levels do not correlate well with those at infection sites. Cavitary lesions, which are the hallmark of human tuberculosis (TB), have limited drug penetration and consequently are a risk factor for treatment failure, recurrence, and the emergence of antibiotic resistance. Direct tissue measurements are invasive, can be performed in humans…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.