NIH R01 · 2025
Blood vessel assembly from multipotent hemangioma-derived stem cells
Abstract Infantile hemangioma (IH) is an extraordinary example of vascular overgrowth wherein vessels form rapidly over a year, then undergo a slow spontaneous involution that leaves behind a fibrofatty residuum. IH is common: it occurs in 5% of infants, equating to ~183,200 infants/year in the U.S. alone. 10-15% of IH will cause complications – e.g., destroy facial structures and impair vision, breathing and feeding depending on the location. Propranolol was discovered serendipitously to be effective therapy for IH, yet some do not respond, regrowth occurs in ~20% of cases, and surgery is needed in 37% of patients to correct IH residua. In the current funding cycle, we showed the non-beta…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.