NIH R01 · 2025
The role of mitochondrial glutathione homeostasis in tumor formation
Project Summary Cancer cells require substantial antioxidant capacity to overcome toxic effects of reactive oxygen species (ROS). Despite their exclusive cytosolic production, cellular antioxidants are also abundantly present in organelles, particularly in mitochondria. In particular, mitochondria, as the source of reactive oxygen species (ROS), require substantial availability of antioxidants to protect its critical redox functions. While previous work suggests a link between mitochondrial redox metabolism and tumor growth, molecular mechanisms involved in maintaining mitochondrial redox homeostasis and the role of mitochondrial antioxidants in tumor progression are poorly understood.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.