Birmann Lab

Brigham and Women's Hospital

Boston · United States

NIH-funded
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Research focus

NIH R01 · 2025

Geospatially modeled environmental risk factors for lymphoid malignancies

Project Summary/Abstract Non-Hodgkin lymphoma (NHL) and multiple myeloma (MM) are cancers arising from mature lymphocytes that collectively pose a substantial public health, personal and financial burden. Present knowledge of their etiology is inadequate to inform prevention strategies; data from prospective studies, and for specific histologic subtypes, are particularly limited. Inflammation, heightened immune activation and growth factor dysregulation contribute to their pathogenesis, as indicated, for example, by well-known associations of NHL risk with severe immune compromise and with pre-diagnosis plasma immune marker profiles that indicate inflammation and B- cell activation, as well…

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