Birder Lab

Research focus

NIH R01 · 2025

PNPase inhibition as an effective treatment for chronic bladder pain

Abstract: Chronic visceral pain disorders, such as interstitial cystitis/bladder pain syndrome (IC/BPS), are among the most difficult types of pain to treat, and response to treatment is often negligible. IC/BPS lacks a well-defined cause, is difficult to diagnose and to date, has no clear therapeutic target. Importantly, both psychological and oxidative stress have been shown to trigger a number of responses which can exacerbate such generalized pain syndromes and may do so by enhancing the effects of pro-nociceptive mediators and promoting oxidative damage. Chronic stress differs from acute or episodic stress as it leads to the persistent elevation of stress mediators that negatively…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.