NIH R01 · 2024
Acute neural injury and posttraumatic epilepsy
PROJECT SUMMARY Posttraumatic epilepsy (PTE) refers to chronic unprovoked seizures following traumatic brain injury (TBI), and is a major clinical problem in both the military and civilian populations. Despite the importance of PTE, the locus of where PTE develops relative to the site of head injury and thus the anatomy of development of PTE in distributed brain networks is not well understood. Consequently, the physiological changes occurring specifically in the PTE seizure focus underlying epilepsy have not been determined. Our long-term goal is to identify mechanisms of PTE. The objective here is to determine the anatomic locus of PTE in the controlled cortical impact (CCI) model of TBI…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.