NIH R01 · 2024
Designer covalent heterobivalent inhibitors to prevent IgE-dependent allergic reactions
Project Summary: Allergic reactions are elicited by the allergen-mediated-clustering of the immunoglobulin E (IgE) antibodies on the surface of mast cells, which is “the key event” in initiation of the systemic reaction. Allergic diseases are increasing health concerns in developed nations. Depending on the severity of the allergic reaction, the results can vary from a simple itch to anaphylactic shock, which results in 1,500 deaths each year in the US. There are no cures for allergies, and current therapies focus on treatment of acute symptoms or chronic immune suppression. Even with the most restricted diets, accidental exposure is very frequent for food allergies, putting patients at…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.