NIH R01 · 2024
Degeneration or breakdown of the myelin sheath that wraps and insulates axons of the central nervous system, as well as peripheral nerves, is a factor in a large array of neurological disorders. These include multiple sclerosis, stroke, age-related neurodegenerative diseases like Alzheimer’s, and in non-neurodegenerative age- related cognitive impairment. To date, myelin breakdown has been assessed indirectly with neurophysiological assays of conduction, post-mortem myelin staining, or in-vivo diffusion MRI. In the normal aging rhesus monkey, post-mortem electron microscopy (EM) has confirmed myelin breakdown at the ultrastructural level; however, EM studies cannot be scaled up to evaluate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.