NIH R01 · 2025
Muscle Mass: a Critical but Missing Component in Muscle Modeling and Simulation
Musculoskeletal simulations that quantify muscle forces during movements, rigorously validated in empirical studies, have great potential to improve life-long mobility for many persons. However, current musculoskeletal simulations generally suffer from physiologically inaccurate muscle models that hinder reliable prediction of time-varying muscle force, which limits their quality and usefulness in the clinic. Although other factors are known to hinder muscle model accuracy, we hypothesize that a fundamental cause is the absence of tissue mass in musculoskeletal models. Inactive muscle mass is most relevant to submaximal activities of daily living (ADL), significantly limiting muscle…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.