NIH R01 · 2025
Immune regulation of arenavirus infections in the placenta
Project Summary. The rodent-borne arenaviruses can cause severe hemorrhagic fevers; several of these potential pandemic pathogens have been noted to cause high rates of maternal mortality, congenital infection, and/or fetal demise when pregnant people are infected. The objective of this project is to determine how arenavirus infection causes adverse pregnancy outcomes. Clinical observations that Lassa virus (LASV) replicates to high titer in the placenta prompted us to conduct a preliminary study using in vitro models of the human placenta and experimental guinea pig infections with an arenavirus that is not pathogenic in humans, Pichinde virus (PICV), to ascertain the role of infection at…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.