NIH R01 · 2025
Controlling Neuropilin-2 Signaling to Improve Lymphatic Function
Lymphatics are vital for fluid recycling, immune surveillance, and lipid uptake. Abnormal lymphatics lead to lymphedema, metabolic changes, inflammation, and infections and contribute to the pathophysiology of many chronic illnesses. In response to the NIH mission (NOT-HL-23-099) promoting research on the biology of the lymphatic system to advance discovery of novel drugs for lymphatic diseases, we have identified Neuropilin-2 (NRP2) as a pivotal manipulator of lymphatic function. NRP2 is a unique transmembrane receptor in lymphatic endothelial cells (LEC) capable of signaling through disparate and opposing ligands. Our central hypothesis is that NRP2 acts as a dynamic rheostat by toggling…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.