NIH R01 · 2024
Regulation of Sister-Chromatid Cohesion in Meiosis
ABSTRACT The long-term goals of my laboratory are to elucidate the mechanisms that regulate sister chromatid cohesion and chromosome segregation during meiosis and to understand why meiotic chromosome segregation errors in human oocytes increase as women age. The incidence of meiotic segregation errors increases dramatically as women age. Such errors are the leading cause of birth defects and miscarriages in humans but the molecular mechanisms underlying this phenomenon (termed the maternal age effect) are not well understood. One prerequisite for accurate chromosome segregation is sister chromatid cohesion, the protein-mediated linkages that hold sister chromatids together. In human…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.