NIH R01 · 2025
Metabolic and xenobiotic control of thyroid hormone metabolism
ABSTRACT Thyroid hormones (TH) play a critical role in development. In the embryo, plasma T3 is relatively low but TH signaling can be enhanced by expression of Dio2, the deiodinase that mediates local T3 production. The timing of the D2-T3 activation varies among tissues, e.g. embryonic day 17 (E17) in brown adipose tissue (BAT), or post-natal day 15 in the cochlea (P15). During the last funding period we discovered a D2-T3 peak in the developing liver (P1-P2), coincidental with the C/EBPa-induced maturation of hepatoblasts to hepatocytes; Dio2 expression in liver is silenced thereafter. By creating a liver-specific Dio2KO mouse (Alb-D2KO) we made the fascinating discovery that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.