NIH R01 · 2025
Glial ion channels in glia/neurons interactions
PROJECT SUMMARY Touch is essential for our survival and for social bonding, and in disrupted in many forms of injuries and disease states. Despite its fundamental importance, touch transduction remains one of the least understood signaling processes, both at the cellular and molecular levels. Touch is mediated by receptors imbedded in the skin, most of which are composed of nerve endings and accessory glial or epithelial cells. Groundbreaking work on the mammalian Merkel cells complex demonstrated that the epithelial cell, rather than the neuron, is the primary sensory cell. However, little is known about the contribution of glia to the function of other touch receptors, including the…
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