NIH R01 · 2025
Diverging roles of EGFR and MET in acetaminophen-induced acute liver injury
Acetaminophen (APAP) overdose is the topmost cause of acute liver failure (ALF) in the United States, with N- acetylcysteine (NAC) as the only available pharmacological treatment. NAC is effective only in early presenting patients, but majority of these patients seek medical attention late. Thus, there is an unmet clinical need to explore alternative pharmacological approaches targeting later stages of ALF, such as by inhibiting progression of injury or by boosting the compensatory liver regeneration. Growth factor receptors, MET and EGFR, are considered essential for liver regeneration after partial hepatectomy (PH), but their roles in the clinically relevant model of APAP-induced liver…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.