NIH R01 · 2024
The Tumor Microenvironment in Nanoparticle Delivery and Function
In response to this IRCN FOA, in this application we have combined our experience of two decades in understanding the tumor microenvironment (TME) with molecular and functional imaging, and our experience of a decade in developing theranostic nanoparticles (NPs) that deliver small interfering RNA (siRNA), to understand the role of TME in siRNA NP delivery and function. siRNA have emerged as promising candidates for precision medicine in cancer that becomes significantly important for cancers such as triple negative breast cancer (TNBC) that lack targeted treatments. Here we will perform combined in vivo PET-MR imaging studies to relate siRNA NP delivery, as detected by PET imaging, to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.