NIH R01 · 2025
Novel mitophagy regulatory mechanism in heart failure
Project Summary: Macro-autophagy and mitophagy (a mitochondria-specific form of autophagy) are constitutively active in the heart and essential to maintaining cardiomyocyte survival under stress by removing potentially harmful proteins and organelles. Extensive studies suggested the occurrence of macro-autophagy and mitophagy impairment early in the pathogenesis of heart failure (HF), but its precise role in HF progression is unclear, and the mechanism(s) of its origin remained elusive. We reported that the Sigma 1 receptor (Sigmar1) is a widely expressed protein in the heart. We have reported that Sigmar1 possesses a physiological role in maintaining healthy heart function, and Sigmar1…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.