NIH R01 · 2024
Targeting Surfactant Protein A to Prevent Retinopathy of Prematurity
PROJECT SUMMARY Retinopathy of prematurity (ROP) is a potentially blinding vaso-proliferative disease frequently seen in prematurely born infants with lifelong consequences for both the infant and society. The c-type lectin, Surfactant Protein A (SP-A), is an immunomodulatory protein, found to be deficient in prematurely born infants. Lack of SP-A is associated with lung disease of prematurity and a temporal association with pulmonary vascular growth factors has been previously reported. We previously discovered that SP-A is expressed in the Müller retina and plays an important role in neovascular disease (NV) with a pro-angiogenic phenotype. Our preliminary data now shows SP-A promotes…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.